The FDA-approved Orbera, initially known as BioEnterics IGB (BIB), is a silicone balloon measuring approximately 13 cm in diameter. Once in place, the intragastric balloon is filled with saline to partially occupy the stomach, reducing hunger and enabling the consumption of smaller food portions while maintaining a satisfying feeling similar to that experienced after larger meals. The majority of weight loss occurs within the initial three months of the balloon’s placement, but since it remains in the stomach for a total of six months, patients can establish habits for the right amount of food to sustain their new weight in the long term. The placement procedure involves introducing the balloon through the mouth via a gastroscopy, with sterile saline filled through a tube attached to the balloon. Recovery time varies, typically allowing patients to return to work within three to five days. While nausea or vomiting may occur initially, medication is prescribed to minimize these effects. The procedure is suitable for patients with diabetes and other illnesses, contributing to improved health and natural weight loss. The intragastric balloon remains in place for six months and is removed through the oesophagus and mouth using an endoscopic camera and catheter, involving puncturing, deflating, grasping, and extraction of the balloon.

The implementation of the Orbera balloon can lead to a weight loss ranging between 20-30 KG by the conclusion of the 12-month period.

The SPATZ3 gastric balloon stands out as a volume-adjustable solution, unlike other balloons that are inflated once and maintain a fixed volume throughout usage. This type of gastric balloon is particularly preferred by individuals with a Body Mass Index exceeding 30, aiming for substantial weight loss. To ensure optimal success, the doctor will determine the necessary pre-screening assessments, which may include a patient information profile, dietary evaluation, general blood tests, and, depending on your age, a chest X-Ray and ECG. Administered endoscopically with conscious sedation, the non-surgical procedure involves placing the balloon in the stomach and inflating it with saline, allowing for discharge within an hour. The balloon can be easily deflated and removed if necessary at any time. In the initial 3-5 days post-procedure, discomfort and symptoms such as nausea, cramping, vomiting, and heartburn may occur but typically subside within a week. A liquid-only diet is recommended for the first three days, gradually progressing to a semi-solid and then solid diet. Adjustments to the balloon volume can be made through a brief 15-minute endoscopy procedure, addressing issues like prolonged nausea or reaching a weight loss plateau. At the end of the treatment period, removal is conducted through endoscopy, preceded by a liquid diet and fasting. Discharge follows promptly after removal.

Unlike the Orbera and Spatz3 weight loss balloons that necessitate endoscopic insertion and inflation, often requiring sedation, the Obalon balloon system introduces a unique and less invasive approach as it eliminates the need for sedation. The patient simply swallows a capsule, similar to ingesting a regular pill, which comes equipped with a thin tube for inflation. Once the capsule’s position in the stomach is confirmed via x-ray, the physician utilizes a device to inflate the balloon, subsequently removing the tube without the requirement for anesthesia. After successful implementation, the patient can return home. Up to three small balloons can be introduced, spaced two weeks apart, with all balloons removed by six months from the initial insertion. Inflated with nitrogen gas and featuring a volume of 250cc, roughly the size of a small orange, the Obalon balloon occupies space in the stomach, inducing a sense of fullness after consuming smaller meals. This facilitates easier control of food intake, contributing to weight loss when combined with appropriate diet and behavior. To determine eligibility for Obalon, a consultation is necessary to comprehensively assess your current health status, medical history, individual condition, and the amount of weight required for improved health, mobility, and enhanced self-confidence. Eligible candidates typically include adults over 22 years old, willing and capable of adhering to a 12-month weight loss program, with a BMI falling within the range of 30 to 40.

Formerly recognized as the ‘Elipse Balloon,’ the Allurion Balloon presents a unique pill balloon capsule that is ingested like a pillow under the supervision of the doctor, eliminating the need for anesthesia or endoscopy. In a quick and efficient outpatient procedure lasting approximately 15 minutes, the balloon is inflated in the stomach and verified using brief x-rays. You will receive support through the Allurion Connected Scale and App throughout the process. This safe and non-permanent solution, endorsed by healthcare professionals, offers the potential for an average weight loss of 10-15% of your body weight in just 16 weeks, complemented by a fully supported 6-month lifestyle program. After approximately 16 weeks, the pill balloon naturally degrades and exits the body. The enduring results extend beyond the balloon’s presence, as you develop new food preferences, adapt to smaller portion sizes, and gain a deeper understanding of your body, fostering sustainable outcomes and avoiding the cycle of constant fluctuations. The Allurion Balloon serves as a secure and temporary catalyst to initiate your weight-loss process​.​

The main difference between the Allurion and Obalon is that Obalon requires endoscopic removal of the balloon. The first one is not (yet) available in the US, being in process of obtaining the FDA approval. It is already available in Europe and some Middle East countries.