Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia Overview

Chronic lymphocytic leukemia (CLL) is a type of chronic leukemia. “Chronic” means that the leukemia usually gets worse slowly. In CLL, the bone marrow makes abnormal lymphocytes (a type of white blood cell). When the abnormal cells crowd out the healthy cells, it can lead to infection, anemia, and easy bleeding. The abnormal cells can also spread outside the blood to other parts of the body. CLL is one of the most common types of leukemia in adults. It often occurs during or after middle age. It is rare in children.

Chronic Lymphocytic Leukemia Symptoms

In the beginning, CLL does not cause any symptoms. Later, you can have symptoms such as:

  • Swollen lymph nodes – you may notice them as painless lumps in the neck, underarm, stomach, or groin
  • Weakness or feeling tired
  • Pain or a feeling of fullness below the ribs
  • Fever and infection
  • Easy bruising or bleeding
  • Petechiae, which are tiny red dots under the skin. They are caused by bleeding.
  • Weight loss for no known reason
  • Drenching night sweats

Chronic Lymphocytic Leukemia Causes

CLL happens when there are changes in the genetic material (DNA) in bone marrow cells. The cause of these genetic changes is unknown, so it’s hard to predict who might get CLL. There are a few factors that might raise your risk.

  • Age – your risk goes up as you get older. Most people who are diagnosed with CLL are over 50.
  • Family history of CLL and other blood and bone marrow diseases
  • Exposure to certain chemicals

Chronic Lymphocytic Leukemia Diagnostics

Your health care provider may use many tools to diagnose CLL:

If you are diagnosed with CLL, you may have additional tests to see whether the cancer has spread. These include imaging tests and bone marrow tests.

Chronic Lymphocytic Leukemia Treatment

Treatments for CLL include:

  • Watchful waiting, which means that you don’t get treatment right away. Your health care provider regularly checks to see if your signs or symptoms appear or change.
  • Targeted therapy, which uses drugs or other substances that attack specific cancer cells with less harm to normal cells.
  • Chemotherapy
  • Radiation therapy
  • Immunotherapy
  • Chemotherapy with bone marrow or stem cell transplant

The goals of treatment are to slow the growth of the leukemia cells and to give you long periods of remission. Remission means that the signs and symptoms of cancer are reduced or have disappeared. The CLL may come back after remission, and you may need more treatment.